Optimize vs Creatine – Which 10X Health Supplement Belongs In Your Routine

10X Health hired Popdust to write this article and provided complimentary products for review purposes. Popdust was not required to provide a positive review.

Most people don’t struggle to find supplements; rather, they struggle to choose the right ones. Without a clear goal, it’s easy to burn money without knowing what’s actually right for your body. 

Enter 10X Health, a health optimization platform that combines genetic and biomarker testing with supplements and clinically guided services. That’s why our editors put two of 10X Health’s foundational products head-to-head: Optimize and Creatine Monohydrate. 

One is designed to provide foundational nutritional support, while the other focuses on strength, performance, and recovery. Both are daily staples that help optimize your body from the inside out, but which one deserves a place on your counter? Let’s find out!

Optimize

Overview

Optimize ($44 or $39.60/every 2 months with subscription) is 10X Health’s daily multivitamin, formulated with bioavailable, methylated nutrients to support key biological processes. It supports energy production, cognitive clarity, cellular health, and nutrient metabolism.* Instead of the conventional forms found in most mass-market multivitamins, it’s formulated with 5-MTHF (an active form of folate), benfotiamine (B1), and pyridoxine (B6), rounded out with NAC, alpha-lipoic acid, and antioxidant compounds for additional cellular support.*

Who it’s for:

• Those who want one go-to multivitamin to cover broad daily nutritional needs
• People looking for a more comprehensive alternative to a basic multivitamin
• People focused on energy, cognitive function, and long-term cellular health
• Anyone who prefers methylated, bioavailable nutrient forms over conventional ones

Our favorite features:

• Methylated nutrient forms (like 5-MTHF) built for better absorption
• NAC and alpha lipoic acid included for antioxidant and cellular support
• Simple once-daily routine 
• Pairs easily with other supplements if you choose to expand your routine

Where it might not be ideal:

• Not designed to target strength or workout performance specifically
• May not be the most direct fit if your only priority is strength or exercise-performance support

These statements have not been evaluated by the FDA. Products are not intended to diagnose, treat, cure, or prevent any disease.

Creatine Monohydrate

Overview

Creatine Monohydrate ($34.99 or $31.49/every 2 months with subscription) delivers 5g of pure, micronized creatine per scoop to support muscle strength, power, exercise performance, recovery, and cellular energy. It’s unflavored and designed to mix easily into water or your preferred beverage, making it simple to incorporate into an existing routine without added sugar, artificial flavors, or unnecessary additives.

Creatine is one of the most researched ingredients in sports nutrition, backed by 500+ published studies. Its benefits go beyond the gym – supporting brain energy metabolism, healthy aging, and key nutrient pathways too.*

Who it’s for:

• Those who train regularly and participate in high-intensity exercise
• Anyone looking to support strength, power, and post-workout recovery*
• People who already have a supplement routine and want a foundational add-on
• Anyone wanting an easy-to-mix creatine without added sweeteners or fillers

Our favorite features:

• 5g of clinically studied, micronized creatine per scoop
• Unflavored and easy to mix into any drink
• No added sugar, sweeteners, or artificial additives
• Vegan, gluten-free, and non-GMO
• Supports strength, power, recovery, and brain metabolism
• Easy to incorporate alongside aminos, electrolytes, or protein

Where it might not be ideal:

• Doesn’t replace a comprehensive daily multivitamin
• Best suited to those with a training routine to support, rather than general daily nutrition

These statements have not been evaluated by the FDA. Products are not intended to diagnose, treat, cure, or prevent any disease.

Our Verdict

If your priority is broad, foundational nutrition, Optimize is the place to start. It delivers steady energy, mental clarity, and cellular support in one clean daily habit. Think of it as the anchor for your routine, whatever that looks like. 

But if you’re training regularly and want targeted support for strength, power, and recovery, choose Creatine Monohydrate. It’s more specific, more performance-driven, and backed by some of the deepest research in sports nutrition.

Our editors recommend keeping both in rotation: Optimize as your daily foundation, and Creatine as the targeted layer on top for anyone serious about training.

*Content is informational only, does not constitute medical advice, and does not guarantee outcomes. Not intended to diagnose, treat, cure, or prevent any disease. Consult a qualified healthcare provider before making any health decisions based on your results.